Description

Peuli 30 is a medicine used to treat uterine fibroids (a non-cancerous growth in the uterus). It is used for intermittent treatment and pre-operative treatment of uterine fibroid in women of reproductive age. Peuli 30 reduces symptoms like vaginal bleeding, prolonged periods and lower back pain. It can be taken with or without food, but take it at the same time to get the most benefit. It should be taken as your doctor’s advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Swallow the tablets whole with a drink of water. You should take this medicine for as long as it is prescribed for you. It is important to note that this medicine makes birth control less effective so use proper contraceptive methods to avoid pregnancy. The most common side effects of this medicine include the absence of menstrual period and headache. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. This medicine might stop your period for some time, but it happens again when you stop taking the medicine. Usually, your periods get stops within 10 days of taking the medicine, consult with your doctor if you still experience heavy bleeding. Before taking this medicine, let your doctor know if you have ever had liver problems or severe asthma. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant or breastfeeding. Your doctor may perform some blood tests to check for liver functioning.

Uses of Peuli 30

Uterine fibroids

Side effects of Peuli 30

Common

Absence of menstrual periods
Headache
Endometrial hyperplasia

How to use Peuli 30

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Peuli 30 may be taken with or without food, but it is better to take it at a fixed time.

How Peuli 30 works

Peuli 30 is a selective progesterone receptor modulator. It works by modifying the action of progesterone (natural female hormone). It is used either before surgery of fibroids or for intermittent (at regular intervals) treatment of fibroids. It helps reduce their size, stops or controls bleeding and increases your red blood cell count.

What if you forget to take Peuli 30?

If you miss a dose of Peuli 30, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Peuli 30 is used for the treatment of uterine fibroids and their associated symptoms, such as painful periods, heavy bleeding and pelvic pain.

It considerably reduces or stops your menstrual bleeding within the first 10 days of treatment. Notify your doctor if you continue to have heavy bleeding despite taking Peuli 30.

Your periods will usually start again within four weeks of stopping Peuli 30.

Use a reliable barrier contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Peuli 30 as it may make hormonal contraceptives (such as pills) less effective.

Your doctor may get routine blood tests done to assess the functioning of your liver. Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.

Indication

Emergency contraception, For pre-operative treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age

Administration

May be taken with or without food.

Adult Dose

Oral Emergency Contraception: One tablet taken orally as soon as possible within 120 hours (5 days) after unprotected intercourse or a known or suspected contraceptive failure. If vomiting occurs within 3 hours of Ulipristal Acetate intake, consideration should be given to repeating the dose. Uterine Fibroids: The treatment consists of 1 tablet of 5 mg to be taken orally once daily for up to 3 months. This 3-month treatment course can be repeated once. Re-treatment should start at the earliest during the second menstruation following the 1st treatment course completion. Treatments should always be started during the 1st week of menstruation. If a patient misses a dose, the patient should take ulipristal acetate as soon as possible. If the dose was missed by >12 hrs, the patient should not take the missed dose and simply resume the usual dosing schedule.

Contraindication

Ulipristal Acetate is contraindicated for use in the case of known or suspected pregnancy. Hypersensitivity to ulipristal acetate or to any of the excipients. Genital bleedng or unknown aetiology or for reasons other than uterine fibroids. Uterine, cervical, ovarian or breast cancer. Breastfeeding.

Mode of Action

Selective progesterone receptor modulator with antagonistic and partial agonistic effects. When taken immediately before ovulation, postpones follicular rupture. It is thought that the primary mechanism of action for emergency contraception is inhibition or delay of ovulation; however, alterations to the endometrium that may affect implantation may also occur.

Precaution

Existing Pregnancy Not indicated for termination of an existing pregnancy. Pregnancy should be excluded before prescribing Ulipristal Acetate. Ectopic Pregnancy A history of ectopic pregnancy is not a contraindication to use of this emergency contraceptive method. Repeated Use Ulipristal Acetate is for occasional use as an emergency contraceptive. It should not replace a regular method of contraception. Repeated use of Ulipristal Acetate within the same menstrual cycle is not recommended, as safety and efficacy of repeat use within the same cycle has not been evaluated. Fertility Following Use A rapid return of fertility is likely following treatment with Ulipristal Acetate for emergency contraception; therefore, routine contraception should be continued or initiated as soon as possible following use of Ulipristal Acetate to ensure ongoing prevention of pregnancy. Effect on Menstrual Cycle After Ulipristal Acetate intake, menses sometimes occur earlier or later than expected by a few days. Contraception Concomitant use of progestagen only pills, a progestagen releasing intrauterine device or combined oral contraceptive pills is not recommended (see Interactions). Although a majority of women taking a therapeutic dose of ulipristal acetate have anovulation, a non hormonal contraceptive method is recommended during treatment. Sexually Transmitted Infections/HIV This does not protect against HIV infection (AIDS) or other sexually transmitted infections (STIs). Endometrial Changes Changes in the histology of the endometrium may be observed in patients treated with ulipristal acetate. These changes are reversible after treatment cessation. These histological changes should not be mistaken for endometrial hyperplasia .

Side Effect

Mood disorders; headache, dizziness; nausea, abdominal pain/discomfort, vomiting; myalgia, back pain; dysmenorrhea, pelvic pain, breast tenderness; fatigue.